2016年版WHO淋巴造血组织肿瘤分类
WHO淋巴造血组织肿瘤分类（2016年版）
骨髓增殖性肿瘤 Myeloproliferative neoplasm（MPN）
慢性髓系白血病，BCR-ABL1 阳性
Chronic myeloid leukemia, BCR-ABL1–positive（CML, BCR-ABL1+）
慢性中性粒细胞白血病
Chronic neutrophilic leukaemia（CNL）
真性红细胞增多症
Polycythemia vera（PV）
原发性骨髓纤维化
Primary myelofibrosis(PMF)
原发性骨髓纤维化，纤维化前/早期
Primary myelofibrosis，prefibrotic/early stage
原发性骨髓纤维化，明显纤维化期
Primary myelofibrosis，overt fibrotic stage
原发性血小板增多症
Essential thrombocythaemia（ET）
慢性嗜酸粒细胞白血病，非特指
Chronic eosinophilic leukaemia, not otherwise specified (CEL, NOS)
骨髓增生性肿瘤，不能分类
Myeloproliferative neoplasm, unclassifiable (MPN,U)
肥大细胞增多症 Mastocytosis
皮肤肥大细胞增多症
Cutaneous mastocytosis(CM)
系统性肥大细胞增多症
Systemic mastocytosis(SM)
肥大细胞白血病
Mast cell leukaemia（MCL）
肥大细胞肉瘤
Mast cell sarcoma (MCS)
皮肤外肥大细胞瘤
Extracutaneous mastocytoma
髓系或淋系肿瘤伴嗜酸性粒细胞增多伴PDGFRA、PDGFRB或FGFR1基因异常，或伴PCM1-JAK2
Myloid lymphoid neoplasams with esonophilia and abnormalities of PDGFRA, PDGFRB ,or FGFRI, or withPCM1-JAK2
髓系/淋系肿瘤伴PDGFRA重排
Myeloid/lymphoid neoplasms with PDGFRA rearrangement
髓系/淋系肿瘤伴PDGFRB重排
Myeloid/lymphoid neoplasms with PDGFRB rearrangement
髓系/淋巴细胞系肿瘤伴FGFR1重排
Myeloid/lymphoid neoplasms with FGFR1 rearrangemen
暂定类型：髓系/淋巴肿瘤伴PCM1-JAK2
Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2
骨髓增生异常/骨髓增殖性肿瘤 Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)
慢性粒-单核细胞白血病
Chronic myelomonocytic leukaemia (CMML)
不典型慢性髓系白血病，BCR-ABL1阴性
Atypical chronic myeloid leukaemia.BCR-ABL1-negative (aCML)
幼年性粒单核细胞白血病
Juvenile myelomonocytic leukaemia (JMML)
骨髓增生异常/骨髓增殖性肿瘤伴环形铁粒幼细胞和血小板增多
Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)
骨髓增生异常/骨髓增生性肿瘤，不能分类
Myelodysplastic/myeloproliferative neoplasm,unclassifiable (MDS/MPN，U)
骨髓增生异常综合征 Myelodysplastic syndrome (MDS)
骨髓增生异常综合征伴单系异型增生
Myelodysplastic syndrome with single lineage dysplasia (MDS-SLD)
骨髓增生异常综合征伴环形铁粒幼细胞
Myelodysplastic syndrome with ring sideroblasts (MDS-RS)
骨髓增生异常综合征伴环形铁粒幼细胞及单系异型增生
Myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia(MDS-RS-SLD)
骨髓增生异常综合征伴环形铁粒幼细胞及多系异型增生
Myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia(MDS-RS-MLD)
骨髓增生异常综合征伴多系异型增生
Myelodysplastic syndrome with multilineage dysplasia(MDS-MLD)
骨髓增生异常综合征伴原始细胞增多
Myelodysplastic syndrome with excess blasts (MDS-EB,MDS-EB1/MDS-EB2)
骨髓增生异常综合征伴孤立性5q-
Myelodysplastic syndrome associated with isolated del(MDS,5q-)
骨髓增生异常综合征，不能分类
Myelodysplastic syndrome, unclassifiable (MDS-U)
暂定类型：幼年性难治性血细胞减少
Provisional entity：Refractory cytopenia ofchildhood
髓系肿瘤伴先天易感性 Myeloid neoplasms with germline predisposition
急性髓系白血病及相关肿瘤 Acute myeloid leukemia (AML)and related neoplasms
急性髓系白血病伴重现性遗传学异常 AML with recurrent genetic abnormalities
急性髓系白血病伴t(8;21)(q22;q22.1)；RUNX1-RUNX1T1
AML with t(8 ;21)(q22;q22);RUNXI-RUNX1Tl
急性髓系白血病伴inv(16)(p13.1;1q22) 或t(16;16) (p13.1; q22)；CBFB-MYH11
AML with inv(16)(p13.1;1q22 )or t(16;16)(p13.1;q22); CBFB-MYHl1
急性早幼粒细胞白血病伴PML-RARA
Acute promyelocytic leukaemia with PML-RARA
急性髓系白血病伴t(9;11)(p21.3;q23.3)；MLLT3-KMT2A
AML with t(9;11)(p21.3;q23.3); MLLT3-KMT2A
急性髓系白血病伴t(6;9)(p23;q34.1)；DEK-NUP214
AML with 1(6;9)(p23;q34.1 ); DEK-NUP214
急性髓系白血病伴inv(3)(q21.3;q26.2) 或 t(3;3)(q21.3;q26.2)；GATA2,MECOM
AML with inv(3)(q21.3;q26.2) 或 t(3;3)(q21.3;q26.2)；GATA2,MECOM
急性髓系白血病（原巨核细胞性）伴t(1;22)(p13.3;q13.3)；RBM15-MKL1
AML (megakaryoblastic) with t(1;22)(p 13.3;q13.3); RBMI5-MKLI
暂定类型：急性髓系白血病伴BCR-ABL1
Provisional entity: AML with BCR-ABL1
急性髓系白血病伴NPM1突变
AML with mutated NPM1
急性髓系白血病伴CEBPA双等位基因突变
AML with biallelic mutations ofCEBPA
暂定类型：急性髓系白血病伴RUNX1突变
Provisional entity: AML with mutatedRUNX1
急性髓系白血病伴骨髓增生异常相关改变 AML with myelodysplasia-related changes
治疗相关髓系肿瘤 Therapy-related myeloid neoplasms
急性髓系白血病，非特指型 Acute myeloid leukaemia，NOS (AML,NOS)
急性髓系白血病伴微小分化
AML with minimal differentiation
急性髓系白血病不伴成熟
AML without maturation
急性髓系白血病伴成熟
AML with maturation
急性粒-单核细胞白血病
Acute myelomonocytic leukaemia
急性原单和单核细胞白血病
Acute monoblastic and monocytic leukaemia
纯红白血病
Pure erythroid leukemia
急性原巨核细胞白血病
Acute megakaryoblastic leukaemia
急性嗜碱性粒细胞白血病
Acute basophilic leukaemia
急性全髓增殖症伴骨髓纤维化 Acute panmyelosis with myelofibrosis (APMF)
髓系肉瘤 Myeloid sarcoma
唐氏综合征（DS）相关的髓系增殖性疾病 Myeloid proliferations related to Down syndrome
短暂性异常骨髓造血
Transient abnormal myelopoiesis（TAM）
DS相关髓系白血病
Myeloid leukaemia associated with Down syndrome
急性未明系别白血病 Acute leukaemia of ambiguous lineage
急性未分化白血病
Acute undifferentiated leukaemia(AUL)
混合表型急性白血病伴t(9;22)(q34.1;q11.2)；BCR-ABL1
Mixed phenotype acute leukaemia with t(9;22)(q34.1;q 11.2)；BCR-ABL1
混合表型急性白血病伴t(v;11q23.3)；KMT2A重排
Mixed phenotype acute leukaemia with t(v;11q23.3)；KMT2A- rearranged
混合表型急性白血病，B/髓系, 非特指型
Mixed phenotype acute Leukaemia，B/myeloid，NOS
混合表型急性白血病，T/髓系，非特指型
Mixed phenotype acute leukaemia，T/myeloid， NOS
混合表型急性白血病，非特指型，少见类型
Mixed phenotype acute leukaemia， NOS，rare types
急性未明系别白血病，非特指型
Acute leukaemia of ambiguous lineage，NOS
母细胞性浆细胞样树突细胞肿瘤
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
前体淋系肿瘤 Precursor lymphoid neoplasms
B 淋巴母细胞白血病/淋巴瘤，非特指型(B-ALL/LBL，NOS)
B lymphoblastic leukemia/lymphoma，not otherwise specified (NOS)
B 淋巴母细胞白血病/淋巴瘤伴重现性遗传学异常
B lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities
B淋巴母细胞白血病/淋巴瘤伴t(9;22)(q34.1;q11.2);BCR-ABL1
B lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2);BCR-ABL1
B淋巴母细胞白血病/淋巴瘤伴t(v;11q23.3);KMT2A 重排
B lymphoblastic leukemia/lymphoma with t(v;11q23.3);KMT2A rearranged
B淋巴母细胞白血病/淋巴瘤伴t(12;21)(p13.2;q22.1); ETV6-RUNX1
B lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1
B淋巴母细胞白血病/淋巴瘤伴超二倍体
B lymphoblastic leukemia/lymphoma with hyper-diploidy
B淋巴母细胞白血病/淋巴瘤伴亚二倍体
B lymphoblastic leukemia/lymphoma with hypo-diploidy
B淋巴母细胞白血病/淋巴瘤伴t(5;14)(q31.1;q32.3) IL3-IGH
B lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3) IL3-IGH
B淋巴母细胞白血病/淋巴瘤伴t(1;19)(q23;p13.3);TCF3-PBX1
B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1
暂定类型：B淋巴母细胞白血病/淋巴瘤，BCR-ABL1样
Provisional entity: B lymphoblastic leukemia/lymphoma, BCR-ABL1-like
暂定类型：B 淋巴母细胞白血病/淋巴瘤伴iAMP21
Provisional entity: B lymphoblastic leukemia/lymphoma with iAMP21
T淋巴母细胞白血病/淋巴瘤T-ALL/LBL T lymphoblastic leukemia/lymphoma
暂定类型： 早期前驱T淋巴母细胞白血病
Provisional entity: Early T-cell precursor lymphoblastic leukemia
暂定类型：自然杀伤细胞淋巴母细胞白血病/淋巴瘤
Provisional entity: natural killer (NK) cell lymphoblastic leukemia/lymphoma
成熟B细胞肿瘤 Mature B-Cell Neoplasms
慢性淋巴细胞白血病/B小淋巴细胞淋巴瘤(CLL/SLL)
Chronic lymphocytic leukemia/small lymphocytic lymphoma
单克隆B细胞淋巴细胞增多症Monoclonal B-cell lymphocytosis
B细胞幼淋巴细胞白血病(B-PLL) B pro-lymphocytic leukemia
脾脏边缘区淋巴瘤(SMZL) Splenic B-cell marginal zone lymphoma
毛细胞白血病(HCL) Hairy cell leukemia
暂定类型：脾脏B细胞淋巴瘤/白血病，未分类
Provisional entity:Splenic B-cell lymphoma/leukemia，unclassifiable
暂定类型：脾脏弥漫红髓小B细胞淋巴瘤Provisional entity:Splenic diffuse red pulp small B-cell lymphoma
暂定类型：毛细胞白血病，变异型(HCL-v)Provisional entity:Hairy cell leukemia-variant
淋巴浆细胞淋巴瘤/华氏巨球蛋白血症
Lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia（LPL/WM）
重链病(HCD)heavy chain disease
Gamma重链病（γ-HCD）Gamma heavy chain disease
Mu重链病（Mu-HCD）Mu heavy chain disease
Alpha重链病（α-HCD）Alpha heavy chain disease
浆细胞肿瘤 Plasma cell neoplasms
意义不明的单克隆γ球蛋白血症Monoclonal gammopathy of undetermined significance (MGUS)
浆细胞骨髓瘤Plasma cell myeloma
骨孤立性浆细胞瘤Solitary plasmacytoma of bone
骨外浆细胞瘤 Extraosseous plasmacytoma
单克隆免疫球蛋白沉积病Monoclonal immunoglobulin deposition diseases (MIDD)
黏膜相关淋巴组织结外边缘区淋巴瘤 (MALT淋巴瘤)
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
结内边缘区淋巴瘤Nodal marginal zone lymphoma（NMZL）
暂定类型：儿童结内边缘区淋巴瘤
Provisional entity:Pediatric nodal marginal zone lymphoma
滤泡性淋巴瘤Follicular lymphoma（FL）
原位滤泡性肿瘤 In situ follicular neoplasia (ISFN)
十二指肠型滤泡性淋巴瘤Duodenal-type follicular lymphoma
儿童型滤泡型淋巴瘤Pediatric type follicular lymphoma
暂定类型：大B细胞淋巴瘤伴IRF4重排
Provisional entity：Large B-cell lymphoma with IRF4 rearrangement
原发性皮肤滤泡中心淋巴瘤
Primary cutaneous follicle center lymphoma(PCFCL)
套细胞淋巴瘤Mantle cell lymphoma(MCL)
原位套细胞肿瘤In situ mantle cell neoplasia (ISMCN)
弥漫大B细胞淋巴瘤，非特指型
Diffuse large B-cell lymphoma (DLBCL), NOS
生发中心B细胞型 Germinal center B-cell type
活化B细胞型 Activated B-cell type
T细胞/组织细胞丰富型大B细胞淋巴瘤
T cell/histiocyte-rich large B-cell lymphoma(THRLBCL)
原发性中枢神经系统弥漫大B细胞淋巴瘤
Primary DLBCL of the central nervous system （CNS DLBCL）
原发性皮肤大B细胞淋巴瘤，腿型
Primary cutaneous DLBCL, leg type（PCLBCL, leg）
EBV阳性弥漫大B细胞淋巴瘤，非特指型
Epstein-Barr virus(EBV)-positiveDLBCL，NOS
暂定类型：EBV阳性皮肤黏膜溃疡
Provisional entity：EBV+ Mucocutaneous ulcer
慢性炎症相关的弥漫大B细胞淋巴瘤
DLBCL associated with chronic inflammation
淋巴瘤样肉芽肿病Lymphomatoid granulomatosis(LYG)
原发性纵隔（胸腺）大B细胞淋巴瘤
Primary mediastinal (thymic) large B-cell lymphoma（PMBL）
血管内大B细胞淋巴瘤Intravascular large B-cell lymphoma(IVLBCL)
ALK+ 大B细胞淋巴瘤ALK positive large B-cell lymphoma(ALK+ LBCL)
浆母细胞性淋巴瘤Plasmablastic lymphoma（PBL）
原发性渗出性淋巴瘤Primary effusion lymphoma（PEL）
暂定类型：HHV8阳性大B细胞淋巴瘤，非特指Provisional entity:HHV8 positive DLBCL, NOS
Burkitt淋巴瘤 Burkitt lymphoma
暂定类型：伴11q异常的伯基特样淋巴瘤Provisional entity：Burkitt-like lymphoma with 11q aberration
高级别B细胞淋巴瘤 High grade B-cell lymphomas
高级别B细胞淋巴瘤伴MYC和BCL-2或BCL6 基因易位
High grade B-cell lymphomas (HGBL), with MYC and BCL2 and/or BCL6 translocations
高级别B细胞淋巴瘤，非特指
High grade B-cell lymphomas，NOS (HGBL，NOS)
特征介于弥漫大B细胞淋巴瘤和经典型霍奇金淋巴瘤之间的未分类B细胞淋巴瘤
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
成熟T和NK细胞肿瘤 Mature T- and NK-Cell Neoplasms
T细胞幼淋巴细胞白血病
T-cell prolymphocytic leukemia(T-PLL)
T细胞大颗粒淋巴细胞白血病
T-cell large granular lymphocytic leukemia(T-LGL)
暂定类型：慢性NK细胞淋巴组织增殖性疾病
Provisional entity：Chronic lymphoproliferative disorder of NK cells（CLPD-NK）
侵袭性NK细胞白血病
Aggressive NK-cell leukemia
儿童系统性EBV阳性T细胞淋巴组织增殖性疾病
Systemic EBV-positive T-cell lymphoproliferative disease of childhood
种痘水疱病样淋巴组织增殖性疾病
Hydroa vacciniforme-like lymphoproliferative disorder
成人T细胞白血病/淋巴瘤
Adult T-cell leukemia/lymphoma (ATLL)
结外NK/T细胞淋巴瘤，鼻型
Extranodal NK/T-cell lymphoma, nasal type
儿童期EBV阳性T细胞淋巴组织增殖性疾病
EBV-positive T-cell lymphoproliferative disorders of childhood
肠病相关T细胞淋巴瘤
Enteropathy-associated T-cell lymphoma（EATL）
单型性亲上皮性肠道T细胞淋巴瘤
Monomorphic epitheliotropic intestinal T-cell lymphoma
暂定类型：消化道惰性T淋巴细胞增生性疾病
Provisional entity：Indolent T-cell lymphoproliferative disorder of the GI tract
肝脾T细胞淋巴瘤
Hepatosplenic T-cell lymphoma（HSTL）
皮下脂膜炎样T细胞淋巴瘤(SPTCL)
Subcutaneous panniculitis-like T-cell lymphoma
蕈样霉菌病
Mycosis fungoides（MF）
Sézary综合征
Sezary syndrome (SS)
原发皮肤CD30阳性T细胞淋巴组织增殖性疾病
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders
淋巴瘤样丘疹病
Lyphomatoid populosis
原发皮肤间变大细胞淋巴瘤
Primary cutaneous anaplastic large cell lymphoma
原发皮肤γ/δT细胞淋巴瘤(PCGD-TCL)
Primary cutaneous gamma-delta T-cell lymphoma
暂定类型：原发皮肤侵袭性亲表皮CD8+ 细胞毒性T细胞淋巴瘤
Provisional entity:Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma
暂定类型：原发皮肤肢端CD8+ T细胞淋巴瘤
Provisional entity:Primary cutaneous acral CD8+ T-cell lymphoma
暂定类型：原发皮肤小／中等CD4+ T细胞增生性疾病
Provisional entity:Primary cutaneous CD4 positive small/medium T-cell lymphoproliferative disorder
外周T细胞淋巴瘤，非特指型
Peripheral T-cell lymphoma, NOS(PTCL, NOS)
血管免疫母细胞性T细胞淋巴瘤
Angioimmunoblastic T-cell lymphoma(AITL)
暂定类型：滤泡性T细胞淋巴瘤
Provisional entity：Follicular T-cell lymphoma (FTCL)
暂定类型：伴TFH表型的结节性外周T细胞淋巴瘤
Provisional entity：Nodal peripheral T-cell lymphoma with TFH phenotype
间变大细胞淋巴瘤，ALK阳性
Anaplastic large cell lymphoma, ALK-positive(ALCL, ALK+)
间变大细胞淋巴瘤，ALK阴性
Anaplastic large cell lymphoma, ALK-negative(ALCL, ALK-)
暂定类型：乳房假体相关间变大细胞淋巴瘤
Provisional entity：Breast implant-associated anaplastic large cell lymphoma
霍奇金淋巴瘤 Hodgkin lymphoma (HL)
结节型淋巴细胞为主型霍奇金淋巴瘤 Nodular lymphocyte predominant Hodgkin lymphoma(NLPHL)
经典型霍奇金淋巴瘤 Classical Hodgkin lymphoma (CHL)
结节硬化型经典型霍奇金淋巴瘤
Nodular sclerosis classical Hodgkin lymphoma( NSCHL)
混合细胞型经典型霍奇金淋巴瘤
Mixed cellularity classical Hodgkin lymphoma（MCCHL）
淋巴细胞丰富型经典型霍奇金淋巴瘤
Lymphocyte-rich classical Hodgkin lymphoma(LRCHL)
淋巴细胞消减型经典型霍奇金淋巴瘤
Lymphocyte-depleted classical Hodgkin lymphoma(LDCHL)
移植后淋巴组织增殖性疾病 Post-transplant Lymphoproliferative Disorders (PTLD)
浆细胞增生性PTLD
Plasmacytic hyperplasia PTLD
传染性单个核细胞增多型 PTLD
Infectious mononucleosis PTLD
多形性PTLD
Polymorphic PTLD
单形性PTLD(B和T/NK细胞型)
Monomorphic PTLD (B- and T/NK-cell types)
经典型霍奇金淋巴瘤型PTLD
Classical Hodgkin lymphoma type PTLD
组织细胞及树状突细胞肿瘤 Histocytic and dendritic cell neoplasms
组织细胞肉瘤
Histiocytic sarcoma
朗格罕细胞组织细胞增生症
Langerhans cell histiocytosis(LCH)
朗格罕细胞肉瘤
Langerhans cell sarcoma(LCS)
交指状树突细胞肿瘤
Interdigitating dendritic cell tumour(IDCT)
交指状树突细胞肉瘤
Interdigitating dendritic cell sarcoma(IDCS)
滤泡树突细胞肉瘤
Follicular dendritic cell sarcoma(FDC)
纤维母细胞性网状细胞肿瘤
Fibroblastic reticular cell tumor
播散性幼年性黄色肉芽肿
Disseminated juvenile xanthogranuloma
脂质肉芽肿病
Erdheim/Chester disease
