2020年版WHO壶腹部肿瘤组织学分类

a.    Intraepithelial tumor/precursors上皮内肿瘤/前驱病变

                                          i.    Adenomatous polyp(intestinal type, serrated)腺瘤性息肉（肠型，锯齿型）

1.    Adenomatous polyp，low-grade

腺瘤性息肉，低级别

2.    Adenomatous polyp，high-grade

腺瘤性息肉，高级别

                                         ii.    Noninvasive pancreaticobiliary papillary neoplasm非浸润性胰胆管乳头状肿瘤

1.    Noninvasive pancreaticobiliary papillary neoplasm，Low-grade dysplasia

非浸润性胰胆管乳头状肿瘤，低级别

2.    Noninvasive pancreaticobiliary papillary neoplasm，High-grade dysplasia

非浸润性胰胆管乳头状肿瘤，高级别

                                        iii.    Intra-Ampulla papillary tubular neoplasm

壶腹内乳头状管状肿瘤

b.    Malignant epithelial tumors恶性上皮性肿瘤

                                          i.    Adenocarcinoma腺癌

1.    Mucinous adenocarcinoma

黏液腺癌

2.    Signet cell carcinoma

印戒细胞癌

3.    Medullary carcinoma

髓样癌

4.    Adenocarcinoma, intestinal type

腺癌，肠型

5.    Adenocarcinoma, pancreaticobiliary type

腺癌，胰胆管型

6.    Tubular adenocarcinoma

管状腺癌

                                         ii.    Neuroendocrine tumor神经内分泌肿瘤

1.    Neuroendocrine tumor, grade 1

神经内分泌肿瘤，G1级

2.    Neuroendocrine tumor, grade 2

神经内分泌肿瘤，G2级

3.    Neuroendocrine tumor, grade 3

神经内分泌肿瘤，G3级

4.    Gastrinoma

胃泌素瘤

5.    Somatostatinoma

生长抑素瘤

6.    Enterochromaffin cell carcinoid

肠嗜铬细胞类癌

7.    Extra-adrenal paraganglioma

肾上腺外副神经节瘤

                                        iii.    Neuroendocrine carcinoma神经内分泌癌

1.    Large cell neuroendocrine carcinoma

大细胞神经内分泌癌

2.    Small cell neuroendocrine carcinoma

小细胞神经内分泌癌

                                       iv.    Mixed neuroendocrine–non-–neuroendocrine neoplasm (MiNEN)

混合性神经内分泌-非神经内分泌肿瘤