2020年版WHO肝和肝内胆管肿瘤组织学分类

a.    Benign hepatocellular tumors良性肝细胞性肿瘤

                                          i.    Hepatocellular adenoma肝细胞腺瘤

1.    HNF1a inactivated hepatocellular adenoma

HNF1a失活性肝细胞腺瘤

2.    Inflammatory hepatocellular adenoma

炎症性肝细胞腺瘤

3.    β-catenin activated hepatocellular adenoma

β-catenin激活型肝细胞腺瘤

4.    β-catenin activated inflammatory hepatocellular adenoma

β-catenin激活型炎性肝细胞腺瘤

b.    Malignant hepatocellular tumors and precursors恶性肝细胞性肿瘤及前驱病变

                                          i.    Hepatocellular carcinoma肝细胞癌

1.    Fibrolamellar

纤维板层型肝细胞癌

2.    Scirrhous

硬化型肝细胞癌

3.    Clear cell type

透明细胞型肝细胞癌

4.    Steatohepatitic

脂肪肝样肝细胞癌

5.    Macrotrabecular massive

巨梁块状型肝细胞癌

6.    Chromophobic

嫌色型肝细胞癌

7.    Lymphocyte rich

富于淋巴细胞型肝细胞癌

                                         ii.    Hepatoblastoma肝母细胞瘤

c.    Benign biliary tumors and a precursors良性胆管肿瘤及前驱病变

                                          i.    Bile duct adenoma

胆管腺瘤

                                         ii.    Adenofibroma

腺纤维瘤

                                        iii.    Biliary intraepithelial neoplasia胆管上皮内瘤变

1.    Biliary intraepithelial neoplasia，Low-grade

胆管上皮内瘤变，低级别

2.    Biliary intraepithelial neoplasia，High-grade

胆管上皮内瘤变，高级别

                                       iv.    Intraductal papillary neoplasm胆管内乳头状肿瘤

1.    Intraductal papillary neoplasm，Low-grade

胆管内乳头状肿瘤，低级别

2.    Intraductal papillary neoplasm，High-grade

胆管内乳头状肿瘤，高级别

                                        v.    Mucinous cystic neoplasm黏液性囊性肿瘤

1.    Mucinous cystic neoplasm，Low-grade

黏液性囊性肿瘤，低级别

2.    Mucinous cystic neoplasm，High-grade

黏液性囊性肿瘤，高级别

3.    With associated invasive carcinoma

伴有浸润性癌

d.    Malignant biliary tumors恶性胆管肿瘤

                                          i.    Cholangiocarcinoma胆管细胞癌

1.    Large duct intrahepatic

肝内大胆管细胞癌

2.    Small duct intrahepatic

肝内小胆管细胞癌

                                         ii.    Carcinoma, undifferentiated

未分化癌

                                        iii.    Combined hepatocellular carcinoma and a cholangiocarcinoma

混合性肝细胞-胆管细胞癌

                                       iv.    Neuroendocrine tumor神经内分泌肿瘤

1.    Neuroendocrine tumor, grade 1

神经内分泌肿瘤，G1级

2.    Neuroendocrine tumor, grade 2

神经内分泌肿瘤，G2级

3.    Neuroendocrine tumor, grade 3

神经内分泌肿瘤，G3级

                                        v.    Neuroendocrine carcinoma神经内分泌癌

1.    Large cell neuroendocrine carcinoma

大细胞神经内分泌癌

2.    Small cell neuroendocrine carcinoma

小细胞神经内分泌癌

                                       vi.    Mixed neuroendocrine–non-–neuroendocrine neoplasm (MiNEN)

混合性神经内分泌-非神经内分泌肿瘤