2020年版WHO结直肠肿瘤组织学分类

a.    Benign epithelial tumor/precursors良性上皮肿瘤/前驱病变

                                          i.    Serrated dysplasia锯齿状异型增生

1.    Serrated dysplasia，Low-grade

锯齿状异型增生，低级别

2.    Serrated dysplasia，High-grade

锯齿状异型增生，高级别

                                         ii.    Adenomatous polyp: Tubular adenoma, villous adenoma, tubulovillous adenoma腺瘤性息肉：管状腺瘤，绒毛状腺瘤，管状绒毛状腺瘤

1.    Adenomatous polyp，Low-grade

腺瘤性息肉，低级别

2.    Adenomatous polyp，High-grade

腺瘤性息肉，高级别

b.    Malignant epithelial tumors恶性上皮性肿瘤

                                          i.    Adenocarcinoma腺癌

1.    Serrated adenocarcinoma

锯齿状腺癌

2.    Adenoma like adenocarcinoma

腺瘤样腺癌

3.    Micropapillary adenocarcinoma

微乳头状腺癌

4.    Mucinous adenocarcinoma

黏液腺癌

5.    Poorly cohesive carcinoma

低黏附性癌

6.    Signet ring cell carcinoma

印戒细胞癌

7.    Medullary adenocarcinoma

髓样腺癌

8.    Adenosquamous carcinoma

腺鳞癌

9.    Undifferentiated carcinoma

未分化癌

10.  Carcinoma with sarcomatoid component

伴肉瘤样成分的癌

                                         ii.    Neuroendocrine tumor神经内分泌肿瘤

1.    Neuroendocrine tumor, grade 1

神经内分泌肿瘤，G1级

2.    Neuroendocrine tumor, grade 2

神经内分泌肿瘤，G2级

3.    Neuroendocrine tumor, grade 3

神经内分泌肿瘤，G3级

4.    L cell tumor

L细胞肿瘤

5.    Glucagon like peptide producing tumor

胰高血糖素样肽生成性肿瘤

6.    PP/PYY producing tumor

PP/PYY生成性肿瘤

7.    Enterochromaffin cell carcinoid

肠嗜铬细胞瘤类癌

8.    Serotonin producing carcinoid

5-羟色胺生成性类癌

                                        iii.    Neuroendocrine carcinoma神经内分泌癌

1.    Large cell neuroendocrine carcinoma

大细胞神经内分泌癌

2.    Small cell neuroendocrine carcinoma

小细胞神经内分泌癌

                                       iv.    Mixed neuroendocrine–non-–neuroendocrine neoplasm (MiNEN)

混合性神经内分泌-非神经内分泌肿瘤