2020年版WHO胆囊与肝外胆管肿瘤组织学分类
a. Benign epithelial tumor/precursors良性上皮性肿瘤/前驱病变
i. Adenoma
腺瘤
ii. Biliary intraepithelial neoplasia胆管上皮内瘤变
1. Biliary intraepithelial neoplasia，Low-grade
胆管上皮内瘤变，低级别
2. Biliary intraepithelial neoplasia，High-grade
胆管上皮内瘤变，高级别
iii. Intracystic papillary neoplasm胆囊内乳头状肿瘤
1. Intracystic papillary neoplasm，Low-grade
胆囊内乳头状肿瘤，低级别
2. Intracystic papillary neoplasm，High-grade
胆囊内乳头状肿瘤，高级别
3. With associated invasive adenocarcinoma
伴有浸润性腺癌
iv. Intraductal papillary neoplasm胆管内乳头状肿瘤
1. Intraductal papillary neoplasm，Low-grade
胆管内乳头状肿瘤，低级别
2. Intraductal papillary neoplasm，High-grade
胆管内乳头状肿瘤，高级别
3. With associated invasive adenocarcinoma
伴有浸润性腺癌
b. Malignant epithelial tumors恶性上皮性肿瘤
i. Adenocarcinoma腺癌
1. Adenocarcinoma, intestinal type
腺癌，肠型
2. PSL adenocarcinoma
PSL腺癌
3. Mucinous cystic neoplasm with associated invasive carcinoma
黏液囊性肿瘤伴浸润性癌
4. Mucinous adenocarcinoma
黏液腺癌
5. Poorly cohesive carcinoma
低黏附性癌
6. Intracystic papillary neoplasm with associated invasive carcinoma
囊内乳头状肿瘤伴有浸润性癌
ii. Squamous cell carcinoma
鳞状细胞癌
iii. Carcinoma, undifferentiated
未分化癌
iv. Adenosquamous carcinoma
腺鳞癌
v. Cholangiocarcinoma
胆管细胞癌
vi. Neuroendocrine tumor神经内分泌肿瘤
1. Neuroendocrine tumor, grade 1
神经内分泌肿瘤，G1级
2. Neuroendocrine tumor, grade 2
神经内分泌肿瘤，G2级
3. Neuroendocrine tumor, grade 3
神经内分泌肿瘤，G3级
vii. Neuroendocrine carcinoma神经内分泌癌
1. Large cell neuroendocrine carcinoma
大细胞神经内分泌癌
2. Small cell neuroendocrine carcinoma
小细胞神经内分泌癌
viii. Mixed neuroendocrine–non-–neuroendocrine neoplasm (MiNEN)
混合性神经内分泌-非神经内分泌肿瘤
