2020年版WHO胰腺肿瘤组织学分类
a. Benign epithelial tumors/precursors良性上皮性肿瘤/前驱病变
i. Serous cystic adenoma浆液性囊腺瘤
1. Macrocystic (oligocystic) serous adenoma
巨囊性（寡囊性）浆液性腺瘤
2. Solid serous adenoma
实性浆液性腺瘤
3. Von Hippel Lindau syndrome associated serious cystic neoplasm
Von Hippel Lindau综合征相关的浆液性囊腺瘤
4. Mixed serous neuroendocrine neoplasm
混合性浆液性-神经内分泌肿瘤
ii. Glandular intraepithelial neoplasia腺上皮内瘤变
1. Glandular intraepithelial neoplasia，Low-grade
腺上皮内瘤变，低级别
2. Glandular intraepithelial neoplasia，High-grade
腺上皮内瘤变，高级别
iii. Intraductal papillary mucinous neoplasm导管内乳头状黏液性肿瘤
1. Intraductal papillary mucinous neoplasm，Low-grade
导管内乳头状黏液性肿瘤，低级别
2. Intraductal papillary mucinous neoplasm，High-grade
导管内乳头状黏液性肿瘤，高级别
3. Associated with invasive adenocarcinoma
伴有浸润性腺癌
iv. Intraductal oncocytic papillary neoplasm导管内嗜酸性乳头状肿瘤
1. Intraductal oncocytic papillary neoplasm，Low-grade
导管内嗜酸性乳头状肿瘤，低级别
2. Intraductal oncocytic papillary neoplasm，High-grade
导管内嗜酸性乳头状肿瘤，高级别
3. Associated with invasive adenocarcinoma
伴有浸润性腺癌
v. Intraductal tubulopapillary neoplasm
导管内管状乳头状肿瘤
vi. Mucinous cystic neoplasm黏液性囊性肿瘤
1. Mucinous cystic neoplasm，Low-grade
黏液性囊性肿瘤，低级别
2. Mucinous cystic neoplasm，High-grade
黏液性囊性肿瘤，高级别
3. Associated with invasive adenocarcinoma
伴有浸润性腺癌
b. Malignant epithelial tumors恶性上皮性肿瘤
i. Ductal adenocarcinoma导管腺癌
1. Colloid carcinoma
胶样癌
2. Poorly cohesive carcinoma
低黏附性癌
3. Signet ring cell carcinoma
印戒细胞癌
4. Medullary carcinoma
髓样癌
5. Adenosquamous carcinoma
腺鳞癌
6. Hepatoid carcinoma
肝样癌
7. Large cell carcinoma with rhabdoid phenotype
具有横纹肌样表型的大细胞癌
8. Carcinoma, undifferentiated
未分化癌
ii. Acinar cell carcinoma腺泡细胞癌
1. Acinar cell cystadenocarcinoma
腺泡细胞囊腺癌
2. Mixed acinar neuroendocrine carcinoma
混合性腺泡-神经内分泌癌
3. Mixed acinar neuroendocrine ductal adenocarcinoma
混合性腺泡-神经内泌-导管腺癌
4. Mixed acinar and ductal adenocarcinoma
混合性腺泡-导管腺癌
iii. Pancreatoblastoma
胰母细胞瘤
iv. Solid pseudopapillary neoplasm of pancreas
胰腺实性-假乳头状肿瘤
c. Pancreatic neuroendocrine neoplasms胰腺神经内分泌肿瘤
i. Pancreatic neuroendocrine microadenoma
胰腺神经内分泌微腺瘤
ii. Neuroendocrine tumor神经内分泌肿瘤
1. Neuroendocrine tumor, grade 1
2. Neuroendocrine tumor, grade 2
胰腺神经内分泌肿瘤，G2级
3. Neuroendocrine tumor, grade 3
胰腺神经内分泌肿瘤，G3级
iii. Pancreatic neuroendocrine tumor, nonfunctioning非功能型胰腺神经内分泌肿瘤
1. Oncocytic
嗜酸细胞型
2. Pleomorphic
多形性
3. Clear cell
透明细胞型
4. Cystic
囊性型
iv. Functioning pancreatic neuroendocrine tumor 功能型胰腺神经内分泌肿瘤
1. Insulinoma
胰岛素瘤
2. Gastrinoma
胃泌素瘤
3. VIPoma
血管活性肠肽瘤
4. Glucagonoma
胰高血糖素瘤
5. Somatostatinoma
生长抑素瘤
6. ACTH-producing tumor
促肾上腺皮质激素生成性肿瘤
7. Enterochromaffin cell carcinoid
肠嗜铬细胞瘤类癌
8. Serotonin producing tumor
5-羟色胺生成性肿瘤
v. Neuroendocrine carcinoma神经内分泌癌
1. Large cell neuroendocrine carcinoma
大细胞神经内分泌癌
2. Small cell neuroendocrine carcinoma
小细胞神经内分泌癌
vi. Mixed neuroendocrine–non-–neuroendocrine neoplasm (MiNEN)混合性神经-非神经内分泌肿瘤
1. Mixed acinar–endocrine carcinoma
混合性腺泡细胞-内分泌癌
2. Mixed acinar–neuroendocrine carcinoma
混合性腺泡细胞-神经内分泌癌
3. Mixed acinar–endocrine–ductal carcinoma
混合性腺泡细胞-神经内分泌-导管癌
